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For adults over 65, no dose adjustment is required, but careful monitoring for adverse effects is prudent as older adults often have multiple comorbidities and medications that increase complication risk

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WeiRZhaoYWangJYangXLiSWangYet alTagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells

Recent studies have revealed that dysregulation of mitochondrial dynamicsincluding impaired mitophagy, imbalances in mitochondrial fusion and fission, and defects in mitochondrial biogenesisis closely associated with CRC initiation, progression, and resistance to therapy [46]

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